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Monoclonal Antibody to Caspase-3 (Clone: ABM11D3)
10-1004
100 ug
€399
Product description
Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death. Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimer's disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis.
Specifications
Applications
FC, IHC, WB
Host
Mouse
Clonality
Monoclonal
Clone
ABM11D3
Isotype
Mouse IgG1
Supplier
Abeomics
Shipping & storage
Shipping condition
Blue Ice
Storage temperature
-20°C
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Productname
Monoclonal Antibody to Caspase-3 (Clone: ABM11D3)
10-1004
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Productname
Monoclonal Antibody to Caspase-3 (Clone: ABM11D3)
10-1004
By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
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