Stimulants belong to a diverse group of psychoactive drugs whose function exerts a constant contribution to hyperactivity and impulse control. Illegal stimulant derivatives including amphetamines, arylcyclohexylamines, cathinones, cocaine/tropanes, phenethylamines, and piperazines are among the most widely abused across the US and Europe. However, the popularity of each substance, particularly in party culture settings, is frequently changing. Cayman offers more than 800 analytical standards for the identification of stimulants and is dedicated to working with the forensic community to quickly make reference standards available for new psychoactive substances (NPS).

Amphetamines

Amphetamine is a synthetic derivative of phenylethylamine, a naturally occurring substance found in chocolate, cheeses, and some wines that looks similar in structure to dopamine. The addition of a methyl group attached to the α-carbon of the phenylethylamine side chain protects amphetamine from degradation by  onoamine oxidases, which enables the effects of amphetamine to persist. While variations of the amphetamine scaffold have been developed by pharmaceutical  companies for treatment of ADHD, appetite suppression, or to slow the progression of Parkinson’s disease (e.g., Adderall, phentermine, and selegiline), designer drug chemists attempting to skirt DEA regulations have also made modifications to the basic amphetamine structure.

Parent compounds

Article number Description Product Status
27889-1 N-Acetylmethamphetamine Not restricted by Dutch Opium law
26596-1 α-ethyl 2C-D (hydrochloride) Not restricted by Dutch Opium law
27184-1 N-benzyl-3,4-DMA (hydrochloride) Not restricted by Dutch Opium law
29844-1 N-(1,4-dimethylpentyl)-3,4-DMA (hydrochloride) Not restricted by Dutch Opium law
13885-5 DOI (hydrochloride) Not restricted by Dutch Opium law
31868-1 Ethiopropamine (hydrochloride) Not restricted by Dutch Opium law

Metabolites

Article number Description Product Status
9001830-5 4-hydroxy Amphetamine (hydrochloride) Not restricted by Dutch Opium law
9002853-1 4-hydroxy Amphetamine Glucuronide (trifluoroacetate salt) Not restricted by Dutch Opium law
30531-1 3,4-Dihydroxyamphetamine (hydrochloride) Not restricted by Dutch Opium law
19208-1 N-Formylamphetamine (CRM) Not restricted by Dutch Opium law

Cathinones

Parent compounds

Article number Description Product Status
27728-1 α-Butylaminohexanophenone (hydrochloride) Not restricted by Dutch Opium law
30598-1 α-Ethylaminohexanophenone (hydrochloride) (CRM) Not restricted by Dutch Opium law
29160-1 4-methyl-α-Ethylaminopentiophenone (hydrochloride) (CRM) Not restricted by Dutch Opium law
29672-1 Eutylone (hydrochloride) (CRM) * Not restricted by Dutch Opium law

Metabolites

Article number Description Product Status
14756-1 Mephedrone metabolite (hydrochloride)
((±)-Ephedrine stereochemistry)
Not restricted by Dutch Opium law
9001434-1 Mephedrone metabolite (hydrochloride)
((±)-Pseudoephedrine stereochemistry)
Not restricted by Dutch Opium law
10518-1 3,4-Methylenedioxy Pyrovalerone metabolite 1 (hydrochloride) Not restricted by Dutch Opium law

Isotopically Labeled Standards

Article number Description Product Status
28819-100 Butylone-d3 (hydrochloride) (CRM) Not restricted by Dutch Opium law
31629-1 Eutylone-d5 (hydrochloride) Not restricted by Dutch Opium law

Sanbio BV is in possession of an opium exemption for trade-related purposes with register number 16455 07 HD.

Download the Stimulant Analytical Standards Brochure here.