Cayman Chemical offers a dedicated tool set to study STING, a central mediator of the innate immune response that induces the expression of various interferons, cytokines, and T cell recruitment factors and has the potential to enhance the initial anticancer response.

This product line features one of their top products, the 2'3'-cGAMP ELISA Kit. This kit enables highly sensitive, direct measurement of 2'3'-cGAMP in cell lysate samples. 2’3’-cGAMP is a second messenger produced by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA.

To compliment this product line, Cayman has developed a novel cGAS Inhibitor Screening Assay Kit that provides a robust and easy-to-use platform for identifying novel inhibitors of human cGAS. Inhibiting cGAS activity can decrease type I IFN production, which could provide a novel way to treat autoimmune diseases. Promoting cGAS activity may have therapeutic utility in producing antitumor responses. This powerful assay can be applied to entire compound libraries to discover cGAS modulators and can be used to profile candidate compounds for inhibitor potency.

cGAS Inhibitor Screening Assay Kit Key Information:

  • Directly measure 2'3'-cGAMP as an indicator of cGAS activity
  • Rapid assay; get results in 3 hours
  • Includes active cGAS enzyme, necessary substrates, and all the assay components needed to run the ELISA
  • cGAS inhibitor CU-76 is also included as a positive control

More information:

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