Modulators of Stem Cell Signaling Pathways
This product line includes activators and inhibitors of signaling pathways that regulate stem cell pluripotency, including TGF-β, BMP4, Wnt, hedgehog, and growth factor signaling pathways. Targets in growth factor signaling pathways include MEK, ERK1/2, and growth factor receptors such as EGFR and FGFR. Cayman offers inhibitors targeting the receptors ALK4, ALK5, and ALK7 in the activin/nodal/TGF-β pathway, as well as pathway activators. Cayman also provides small molecules targeting the receptors ALK1, ALK2, ALK3, and ALK6 in the BMP4 pathway, GSK3β in the Wnt signaling pathway, and Smoothened (Smo) in the hedgehog pathway, as well as compounds to control apoptosis occurring during stem cell self-renewal and proliferation.
Cayman’s Stem Cell Small Molecule Screening Library (96-Well) contains more than 140 small molecules and is designed to simplify screening efforts. This library includes compounds that induce differentiation, maintain self-renewal and proliferation, or improve the reprogramming efficiency of various stem cell populations.