Polyclonal Antibody Sequencing
Sequencing polyclonal antibodies in order to secure a precisely defined and reproducible source of antibodies has been an impossibility, until now. Absolute Antibody partnered with leading industry innovators to offer a polyclonal antibody immortalization service.
Polyclonal antibodies are widely used reagents across research and diagnostics. They are generated by immunizing animals with an immunogen and harvesting the animals’ blood to obtain immunoreactive serum. While polyclonal antibodies offer a range of advantages such as excellent performance across different methods, they suffer from high batch-to-batch variability and require the continued use of animals for their production.
Turning a polyclonal antibody into an infinitely reproducible recombinant antibody has been described as the Holy Grail of reagent antibody technology with far-reaching potential. Now, advances in antibody protein sequencing technology have made it possible to sequence a polyclonal antibody protein sample and obtain highly functional recombinant monoclonal antibodies from the sequence.