From the discovery of biomarkers for rare diseases to improving our understanding of the progression of Alzheimer’s disease, lipid research is showing significant potential in the field of bioscience. Thanks to recent advancements in mass spectroscopy (MS), lipid research has ever-growing applications in bioscience.
Lipids: the bare necessities of life
Lipids are vital building blocks of living organisms, essential to cell structure and signaling, and energy metabolism. Lipids are a very large family of non-homogenous compounds that typically consist of two hydrophobic, fatty acid tails, a glycerol backbone and a hydrophilic phosphate head. According to the LIPID Metabolite and Pathway Strategy (LIPID MAPS) project, lipids can be categorised into eight major groups: fatty acyls, glycerophospholipids, glycerolipids, sterol lipids, sphingolipids, polyketides, prenol lipids and saccharolpidpids.1
By virtue of their partially hydrophobic nature, lipids are the physical foundation of all living systems, providing the lipid bilayer cell wall that separates living cells from their environment. Lipids have vital functions in extra- and intracellular signal transduction and in the magnification of cellular regulatory cascades.2 Lipids are major participants in the conversion of energy within cells, the transportation of substances, and cell growth, differentiation and apoptosis. As lipids have such critical biological roles, any deviations from their regular function can result in a variety of diseases.
The dawn of lipid research
Lipid research encompasses the large-scale profiling of cellular lipids, the quantification of specific lipids in biological samples and the documentation of the interactions between lipids and other lipids, proteins and metabolites within the body.3 Serious developments in the field have occurred in recent memory, thanks to significant advances in MS and biobanking. Lipid analysis can be challenging due to the sheer number of different cellular lipids, which can range from tens to hundreds of thousands, and their varied concentration in samples. On top of this, lipids are changing constantly in response to changes in their environment and interactions with metabolites.4
Lipids are highly diverse and dynamic molecules which can make profiling an arduous task. Before the implementation of high-throughput lipodomics, lipid profiling was time-consuming and extremely limited. Technological advances in MS techniques have revolutionised the field, enabling the profiling of thousands of lipids in a single assay. Today, lipid research has started to map the lipidome of human cells and describe lipid biological pathways. The rate at which our understanding of lipid behaviour is changing looks set to revolutionise the way we diagnose and treat many diseases.
How lipid research is shaping the future of bioscience
Oncology
Cancerous cells undergo major changes in lipid metabolism, meaning that lipids play a major role in the proliferation of cancerous tumours.4 Lipid research can monitor these changes to discover novel biomarkers for earlier diagnosis. Also, both quantitative and qualitative analysis of lipids in bodily fluids is proving to be a valuable tool for monitoring treatment efficacy and toxicity.4 For example, eicosanoids have been identified to play a role in cancerous cells’ neoplastic transformations and blocking eicosanoid receptors can impede the inflammatory response of tumour cells.6
Metabolic syndromes
Lipid research plays a pinnacle role in understanding how to treat metabolic-syndrome-related diseases like diabetes. Lipidomic techniques are highly utilised for mechanistic assays, risk prediction, and monitoring treatment efficacy. Recent lipid research has shown that phospholipids are key bioactive constituents of high-density lipoprotein (HDL), providing new evidence in favour of the efficacy of HDL therapies in treating cardiovascular disease.7
Neurological disorders
Lipids are major components of the brain, required for signaling, metabolism, trafficking and homeostasis, making lipid research fundamental to studying neurological disorders. Lipid research has revealed the association between long-chain cholesterol esters and Alzheimer’s disease, providing potential novel therapeutic targets such as cholesteryl esters and HDL-C.8
Precision medicine
The most recent direction of lipid research is towards precision medicine. Lipids make up a large proportion of all metabolites, making them important potential biomarkers. Lipid research is accelerating the discovery of biomarkers and the development of targeted therapies, helping to path the way in more personalised therapies for many diseases, from rare metabolic diseases to atherosclerosis.
The ever-growing applications of lipid research in bioscience looks highly promising for this vital research field. With its ever-expanding applications, lipid research is now helping genomic and proteomic research to path the way to better patient diagnosis, treatment and overall outcomes in bioscience.
Looking for lipid research products?
Explore our comprehensive range of over 3,500 lipid research products from Cayman Chemical. From high-purity fatty acyls to glycerophospholipids, our offerings include isotopically labelled standards and ELISAs for biomarker discovery and quantitative detection. Contact our us.
References
Fahy, E., Subramaniam, S., Murphy, R.C., Nishijima, M., Raetz, C.R.H., Shimizu, T., Spener, F., van Meer, G., Wakelam, M.J.O. and Dennis, E.A. (2009). Update of the LIPID MAPS comprehensive classification system for lipids. Journal of lipid research, [online] 50 Suppl(Suppl), pp.S9-14. doi: https://doi.org/10.1194/jlr.R800095-JLR200.
Züllig, T., Trötzmüller, M. and Köfeler, H.C. (2019). Lipidomics from sample preparation to data analysis: a primer. Analytical and Bioanalytical Chemistry, 412(10), pp.2191–2209. doi: https://doi.org/10.1007/s00216-019-02241-y.
Valerie Bridget O'Donnell, Ekroos, K., Gerhard Liebisch and Michael J.O. Wakelam (2019). Lipidomics: Current state of the art in a fast moving field. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 12(1). doi: https://doi.org/10.1002/wsbm.1466.
Yang, K. and Han, X. (2016). Lipidomics: Techniques, Applications, and Outcomes Related to Biomedical Sciences. Trends in Biochemical Sciences, 41(11), pp.954–969. doi: https://doi.org/10.1016/j.tibs.2016.08.010.
Titz, B., Gadaleta, R., Lo Sasso, G., Elamin, A., Ekroos, K., Ivanov, N., Peitsch, M. and Hoeng, J. (2018). Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification. International Journal of Molecular Sciences, [online] 19(9), p.2775. doi: https://doi.org/10.3390/ijms19092775.
Virgili, E., Emili, R., Ferri, H., Palermo, F., Calza, L., M Gardarelli and Spina, M. (2018). Lipidomics and Nutrylipidomics in Oncology: Review of the Literature. Journal of bioinformatics and systems biology, 01(01). doi: https://doi.org/10.26502/jbsb.5107002.
Darabi, M., Guillas-Baudouin, I., Le Goff, W., Chapman, M.J. and Kontush, A. (2016). Therapeutic applications of reconstituted HDL: When structure meets function. Pharmacology & Therapeutics, [online] 157, pp.28–42. doi: https://doi.org/10.1016/j.pharmthera.2015.10.010.
Petroula Proitsi, Kim, M., Whiley, L., Pritchard, M., Leung, R., Hilkka Soininen, Iwona Kłoszewska, Patrizia Mecocci, Tsolaki, M., Vellas, B., Sham, P., Lovestone, S., Powell, J., Dobson, R. and Legido-Quigley, C. (2015). Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer’s disease. Translational Psychiatry, 5(1), pp.e494–e494. doi: https://doi.org/10.1038/tp.2014.127.
From the discovery of biomarkers for rare diseases to improving our understanding of the progression of Alzheimer’s disease, lipid research is showing significant potential in the field of bioscience. Thanks to recent advancements in mass spectroscopy (MS), lipid research has ever-growing applications in bioscience. Lipids: the bare necessities of life Lipids are vital building blocks […]
The psychedelic drug references standards from Cayman Chemical are qualified ISO-accredited reference materials for a wide range of naturally derived and synthetic psychoactive substances. Cayman Chemical specialise in the synthesis, purification and characterisation of novel compounds including the Tryptamines and Entheogen family for research and drug discovery applications.
While psychedelic drugs are currently designated as controlled substances, some are demonstrating medicine benefits and are used in clinical studies for examining disease treatment.
With an expanding line of psychedelic compounds, these nove
l compounds are manufactured in DEA-regulated facilities and are supplied in both milligram and gram quantities. These reference standards are ideal for clinical studies, research and drug discovery.
Benefits of these psychedelic drug reference standards
Qualified ISO-accredited reference material
Manufactured in DEA-regulated facilities
Available for naturally derived and synthetic psychoactive substances
Products that fall within the drug reference material range may be considered a controlled product. We will require confirmation that you possess the necessary Opium Waiver from Farmatec (NL) or the FAGG (BE) for a controlled product to be supplied to you. These products may also be subject to additional fees for the handling and processing of your order.
Since Sanbio is a Dutch company, we cannot promote controlled products on our website. All products available on www.caymanchem.com can be supplied by Sanbio. Feel free to reach out to our specialists to get more information about your product of interest: nheijmans@sanbio.nl or support@sanbio.nl.
The psychedelic drug references standards from Cayman Chemical are qualified ISO-accredited reference materials for a wide range of naturally derived and synthetic psychoactive substances. Cayman Chemical specialise in the synthesis, purification and characterisation of novel compounds including the Tryptamines and Entheogen family for research and drug discovery applications. While psychedelic drugs are currently designated as [...]
Cayman Chemical’s forensic range includes over 600 opioid analytical reference standards and ISO 17034-produced Certified Reference Materials (CRMs) to identify and quantitatively measure these drugs of abuse. In response to the opioid epidemic, Cayman has worked in close collaboration with the forensic community to expand its catalogue to include a wide collection of fentanyls and other emerging synthetic opioids as well as plant-derived opiates, their metabolites and internal standards.
Products that fall within the drug reference material range may be considered a controlled product. We will require confirmation that you possess the necessary Opium Waiver from Farmatec (NL) or the FAGG (BE) for a controlled product to be supplied to you. These products may also be subject to additional fees for the handling and processing of your order.
Since Sanbio is a Dutch company, we cannot promote controlled products on our website. All products available on www.caymanchem.com can be supplied by Sanbio. Feel free to reach out to our specialists to get more information about your product of interest: nheijmans@sanbio.nl or support@sanbio.nl.
Cayman Chemical’s forensic range includes over 600 opioid analytical reference standards and ISO 17034-produced Certified Reference Materials (CRMs) to identify and quantitatively measure these drugs of abuse. In response to the opioid epidemic, Cayman has worked in close collaboration with the forensic community to expand its catalogue to include a wide collection of fentanyls and [...]
The cannabis reference materials range from Cayman Chemical includes a wide range of analytical standards and ISO 17034-produced Certified Reference Materials which can be used for the identification and quantification of components found in cannabis products.
Cayman Chemical offers authentic reference standards for the most prominent of these phytocannabinoids, many of their metabolites, including different tetrahydrocannabinol, CBD and CBG, ideal for analytical laboratories which carry our CBD/THC testing and analysis of CBD products.
Along with single-component standards for potency testing, terpene profiling and contaminants analysis, Cayman specialise in the production of pre-made, multi-component mixtures that are designed to improve quantitation accuracy and streamline workflows.
Benefits of these reference materials
Single- and multi-component mixtures available
Manufactured and tested to meet ISO/IEC 17025 & ISO 17034 international standards
Sold as quantitative solutions in sealed ampules
Given a certified property and uncertainty value for metrological traceability
Products that fall within the drug reference material range may be considered a controlled product. We will require confirmation that you possess the necessary Opium Waiver from Farmatec (NL) or the FAGG (BE) for a controlled product to be supplied to you. These products may also be subject to additional fees for the handling and processing of your order.
The cannabis reference materials range from Cayman Chemical includes a wide range of analytical standards and ISO 17034-produced Certified Reference Materials which can be used for the identification and quantification of components found in cannabis products. Cayman Chemical offers authentic reference standards for the most prominent of these phytocannabinoids, many of their metabolites, including different [...]
At Bethyl Laboratories, part of Fortis Life Sciences, they offer a range of custom antibody production and nanomaterial synthesis services to help overcome the research and development challenges within your business. For many of their clients, they realize that cutting-edge research requires custom solutions. Therefore, they are pleased to offer custom products and services, where their team of experienced scientists can ensure a successful outcome to projects across a wide range of scientific applications.
Custom Monoclonal Antibodies
Recombinant monoclonal antibodies can be custom made to meet your project-specific requirements by their expert team. They generate numerous candidates for you to test in your assays and workflows, in order to mitigate risk in the project.
Custom Polyclonal Antibodies
As specialists in production and purification of high-quality polyclonal antibodies, they offer custom polyclonal antibody production services, with the possibility of transitioning to a monoclonal antibody project at a later date.
At Bethyl Laboratories, part of Fortis Life Sciences, they offer a range of custom antibody production and nanomaterial synthesis services to help overcome the research and development challenges within your business. For many of their clients, they realize that cutting-edge research requires custom solutions. Therefore, they are pleased to offer custom products and services, where […]
Looking for AAV-related products? We can provide you with different AAV-related products such as antibodies, ELISAs, standards and more from our supplier PROGEN?
The adeno-associated virus (AAV) is a small, non-enveloped virus and have a single-stranded DNA (ssDNA) genome of approximately 4.7 kb. Twelve different AAV serotypes are known.
The AAV genome is flanked by two terminal repeats (ITRs) essential for packaging the viral DNA, replication, transcription and site-specific integration. The genome consist of the Rep gene that encodes four rep proteins which are essential for DNA replication, packaging the viral genome and its integration into the host DNA. Also the Cap gene is present in its genome which encodes three viral capsid proteins (VP) that form the virus capsid.
AAV is interested to several gene therapy researcher due to several features such as lack of pathogenicity, the ability to also infect non-dividing cells and has the ability to stably integrate into the host genome at a specific site.
AAV derived vectors possesses very low cytotoxicity and low immunogenicity and rarely integrate into the genome but reside as episomes in the nucleus, lowering the chance of spontaneous gene alteration. AAV enables long-term transgene expression so in theory genes only need to be delivered once. These features makes the AAV-derived vectors a perfect vehicle for the delivery of genetic material to human cells.
We can provide you with many different AAV-related products such as antibodies, ELISAs, standards Dip’n’Check lateral flow tests and Optiprep™ solution for purification of viral particles from our supplier Progen.
Antibodies
The antibodies are great tools to characterize the different stages of AAV infection and to analyze the AAV assembly process. The AAV capsid protein antibodies recognize the linear epitopes of the viral capids, so specifically reactis with denaturated AAV capsid proteins. The AAV particle antibodies recognize a conformational epitope of the assembled capsids, so specifically react with intact AAV particles. Also AAV replicase antibodies are available for your research.
AAVrh74 recognized by ADK8 AAV8 and ADK8/9 AAV8 & AAV9
Anc80 recognized by A20 AAV2 and ADK8 AAV8
AAVDJ recognized by ADK8/9 AAV8
ELISAs
You can rely on PROGEN’s AAV ELISAs to consistently deliver dependable capsid titer determination. For most commonly used AAV serotypes both AAV titration ELISAs and Xpress ELISAs are available. The assay time of the Xpress ELISAs is reduced more than 50% compared to standard kits, so results in less than two hours. Both PROGEN’s AAV ELISA and AAV ELISA Xpress kits have a reference standard status in gene therapy centers worldwide.
AAV type
Titration ELISA Cat No.
Xpress ELISA Cat No.
AAV1
PRAAV1
AAV2
PRATV, PRAAV2R
PRAAV2XP
AAV3
PRAAV3R
AAV5
PRAAV5
PRAAV5XP
AAV6
PRAAV6
PRAAV6XP
AAV8
PRAAV8
PRAAV8XP
AAV9
PRAAV9
PRAAV9XP
AAVrh10
PRAAV10
Standards
PROGEN’s fully characterized AAV standards are prefect to monitor the validity of your results and to ensure comparability of your assays.
AAV Empty Capids (AAV1, AAV2, AAV5, AAV6, AAV8 and AAV9) are offered in liquid form with high titers of more than 5.0E+12 viral particles/ml and can be used as reference material in a variety of applications including ELISA, Western blot and dot blot.
AAV ELISA controls can be used as positive controls with the corresponding AAV ELISAs.
AAV VP Capsid protein standards can be used to monitor VP1, VP2 and VP3 protein concentrations and their molar ratios to ensure initial optimization and consistent quality of your final AAV gene therapy products
Testing individual and crude AAV samples quick during development and manufacturing is often difficult, because most accurate analytical AAV tools are not convenient for single sample measurement and/or require highly purified samples. PROGEN’s AAV Dip’n’Check lateral flow test are quick and easy to check the AAV capsid purification process and ideal for analytical pre-testing.
Detection of AAV1 and AAV6 capsids: Cat No. PR5216
Detection of AAV2 and AAV3 capsids: Cat No. PR5223
Detection of AAV8 capsids: Cat No. PR5208
Detection of AAV9 capsids: Cat No. PR5209
Optiprep™ solution
Optiprep™ Cat.no 1893 is the ideal solution for virus purification such as AAV, because the ratio of infectious particles to total particles is 100 times higher using Optiprep™ gradients compared to CsCl gradients.
Using OptiPrepTM for AAV purification saves time, because no need to remove iodixanol for most downstream processes, it causes little or no damage to viral particles, results in a then times greater recovery rate than CsCl gradient alternatives and results in a higher infectively titer with no toxic effects.
Looking for AAV-related products? We can provide you with different AAV-related products such as antibodies, ELISAs, standards and more from our supplier PROGEN? The adeno-associated virus (AAV) is a small, non-enveloped virus and have a single-stranded DNA (ssDNA) genome of approximately 4.7 kb. Twelve different AAV serotypes are known. The AAV genome is flanked by [...]
Stable Cell Line Development Service by OriGene
Generating custom cell lines is a tedious and complex process. OriGene offers a custom stable cell line development service that can be designed for knockdown, knock-in, or knockout of virtually any protein of interest (constitutive and inducible options available). Take advantage of their expertise in gene expression and highly effective gene delivery technologies to produce high-quality cell lines.
What they offer
Over Expression (ORF)
Inducible
Constitutive
Knockdown (shRNA)
Inducible
Constitutive
Knock-in (CRISPR)
Knockout (CRISPR)
Service Highlights
Fast turnaround time: 2-3 months
Choose from OriGene’s extensive ORF clone collection or provide your own expression cassette
Rigorous and customizable QC validation process
Professional, Global Technical Support
Cell Line Development Workflow
Inducible Stable Cell Line Development
Inducible expression is a valuable tool for functional analysis of assay systems with toxic targets. OriGene's All-in-one Tet-On system is a new and improved version of the original Tet-On systems, designed to significantly stimulate expression of the downstream gene of interest (GOI).
Custom Overexpression stable cell lines by System BioSciences
Reliable, high-quality custom stable cell line generation for overexpression of your protein- or regulatory RNA-of-interest
Leverage SBI’s viral and non-viral vectors in robust overexpression cell lines
Whether you want constitutive or inducible overexpression of a protein or regulatory RNA, SBI’s services team can create the construct and the cell line. They have access to a range of technologies—including stably integrating viral and non-viral vectors—and an expert team experienced at working with a variety of cell lines, including adherent and suspension cells. The result is hundreds of successfully constructed stable cell lines for highly satisfied customers.
Why choose SBI’s Stable Cell Line Services?
Save time by having SBI build your custom cell lines
Leverage our highly-regarded gene expression and delivery technologies
Accomplish more with our fast turnaround times and end-to-end services
Turn to the company that other companies turn to—we are a trusted stable cell line manufacturer for many large pharma/biotech companies
Enjoy consistent quality, confidentiality, and on-time delivery with all projects completed on-site in our Palo Alto, CA, facility
Available gene expression and delivery technologies
Stable Cell Line Development Service by OriGene Generating custom cell lines is a tedious and complex process. OriGene offers a custom stable cell line development service that can be designed for knockdown, knock-in, or knockout of virtually any protein of interest (constitutive and inducible options available). Take advantage of their expertise in gene expression and [...]
UltraMAB Antibody Specificity Service
The Ultimate Array test for Validating Antibody Specificity
High specificity is the pre-requisite for any antibody used in diagnostic and therapeutic applications. Antibody cross-reactivity will create unexpected side effects of false diagnostic reports for clinicians. Research data from various groups have shown that some monoclonal antibodies on the market are not mono-specific. However, there was no commercial tool available to test the specificity of an antibody thoroughly.
OriGene Offers A Solution: UltraMAB Array Test OriGene now provides UltraMAB Service, the ultimate array test to validate the antibody specificity. The UltraMAB Service leverages OriGene's proprietary technology platform, the High-Density Protein Microarray, to test the specificity of an antibody against the human proteome in a high-throughput manner. This platform can also be used to screen for the target(s) of an antibody or a small molecule.
What is High-Density Protein Microarray?
With a large collection of overexpression antigen standards, OriGene developed a high-density protein microarray chip for antibody evaluation at the proteome-wide level. This protein chip is spotted with over 10,000 overexpression proteins in duplicate on a single nitrocellulose coated glass slide, as well as various positive and negative controls. The array was manufactured as indicated in the flow chart below and tested with 1:500 dilution of OriGene's anti-DDK (FLAG) tag antibody followed by DyLight 649 conjugated goat anti-mouse IgG secondary antibody.
Specifications of the High-Density Protein Microarray
OriGene protein microarray slide specifications:
Slide type:
White nitrocellulose glass slide
Slide NC pad dimension:
20mm x 60mm
Total subarrays:
48 (4 columns x 12 rows)
Subarray Size:
4200um x 4400 um
Subarray Dimensions:
21 rows (Vertical) x 22 columns (Horizontal)
Median Spot Diameter:
~120um
Spot Center to Center Spacing:
200um
Distances Between Subarrays:
100um
Replicates per Sample:
2
Under current specifications of the 10K microarray chip, 10,728 samples were spotted in duplicates on a single nitrocellulose slide. These include 10,020 overexpression lysates and 708 positive and negative control samples. The premium 17K chip contains 16,242 overexpression lysates. Serial diluted mouse, human and rabbit IgG mixture as positive controls were spotted on three subarrays highlighted in redboxes. Subarrays highlighted in yellowboxes contain serial diluted HEK293T cell lysates as negative controls. All the subarrays contain standard positive and negative controls as shown in the figure above. The major protein family coverage is shown in the figure below.
UltraMAB Array Test - Scope of Service
With the UltraMAB array service, OriGene helps you identify reactive proteins of your antibody and potential off-target effects to eliminate the cross-reactivity concerns. Please refer to the flow chart below for the details of this service
The current service offers our standard 10,000 or platinum 17,000 human protein array. The average timeline for array chip test and data analysis is 3 weeks upon receiving customer's antibody.
UltraMAB Antibody Specificity Service The Ultimate Array test for Validating Antibody Specificity High specificity is the pre-requisite for any antibody used in diagnostic and therapeutic applications. Antibody cross-reactivity will create unexpected side effects of false diagnostic reports for clinicians. Research data from various groups have shown that some monoclonal antibodies on the market are not [...]
With more than 30 years of experience in the synthesis, purification, and characterization of biochemicals, Cayman Chemical has become a leader in the field of designer drugs by providing high-purity reference standards to federally licensed laboratories and qualified academic research institutions for forensic analysis. Cayman’s highly trained staff of chemists provide institutions with solutions to quickly identify and understand the physiological and toxicological properties of new designer drugs. Cayman synthesizes a range of analytical standards including synthetic cannabinoids, cathinones, phenethylamins, amphetamines, indanes, opioids, benzodiazepines, tryptamines, and phytocannabinoids, among many others.
Sanbio BV is in possession of an opium exemption for trade-related purposes with register number 16455 07 HD.
Cayman’s Reference Materials (RMs) are sold in several sizes allowing for a low-cost, scalable, and highly flexible option for analytical labs. An RM is fully characterized, and its property values are tested under an ISO/IEC 17025:2017 accredited quality system, making it fit for direct use by labs requiring traceable standards.
Certified Reference Material (CRM)
Certified Reference Materials (CRMs) serve as Primary Standards as defined by ISO and are suitable for labs requiring traceable quantitative standards. A CRM, as defined by ISO 17034:2016, must report the certified concentration and corrected purity values with the corresponding measurement uncertainties. Cayman’s CRMs ensure the metrological traceability and accuracy needed to perform quantitative measurements and are sold as quantitative solutions in sealed ampules.
Analytical Standards
Cayman’s Forensic Analytical Standards are accompanied by testing documentation to demonstrate purity and identity characterization and are formulated in small quantities as neat solids or in solution for use in analytical testing. They may be suitable for application in identification, analytical method validation, and quantification. However, analytical methods requiring quantification may require assessment of suitability or in-house verification to meet laboratory specifications and accreditations. Most Reference Materials are initially produced as Analytical Standards in order to make the Reference Material quickly available for use.
Forensic Science products by Cayman Chemical With more than 30 years of experience in the synthesis, purification, and characterization of biochemicals, Cayman Chemical has become a leader in the field of designer drugs by providing high-purity reference standards to federally licensed laboratories and qualified academic research institutions for forensic analysis. Cayman’s highly trained staff of […]
Blood and Biospecimens for precision medical research by Research Donors
Who are Research Donors?
Research Donors is an HTA-licensed clinic, based in London, dedicated to the collection and processing of human blood and fresh leukopaks for research purposes. Research Donors is ISO 9001 2015 certified with Research Ethics (REC) approval as a Research Tissue bank, and participates in the UK NEQAS QA scheme.
Sourcing human blood and biospecimens for research can be challenging, complex and time consuming. The complete service of Research Donors is here to help you source high-quality human blood and tissue samples for research.
The fresh human leukopaks of Research Donors are a source of highly concentrated peripheral blood mononuclear cells (PBMC) from a single donor, with a range of sizes available depending on your requirements. Collections are tailored to each researchers' specific needs, so the choice of volume, shipment temperature and blood group is yours.
Benefits of using fresh leukopaks of Research Donors • 10 billion total nucleated cells per donor on average from a full leukopak
• Delivery the next day after collection (in the BeNeLux)
• Fresh leukopaks collected to your exact research requirements
• High-viability PBMCs with minimal degradation
• Fresh leukopak collection available 4 days per week
• Comprehensive donor information provided, including full blood counts
• Collected at an HTA-licensed, ISO 9001 2015 certified facility
• Samples fully consented including for genetic analysis, animal models and commercial research purposes
• Large donor pool
• Available in full, half and quarter bags or 15-20 ml (500 million TNCs) sizes
• Donors pre-screened for HIV, HBV, HCV, Syphilis, HTLV I and HTLV II
Research Donors offers fresh and frozen peripheral blood mononuclear cells (PBMC). The PBMCs are processed within 5 hours of blood collection for minimal degradation, with HLA typing available on request.
Benefits of the fresh PBMC service
• Delivery on the next day after collection (in the BeNeLux)
• Processed within 5 hours of blood collection for minimal degradation
• Specific donor/protocol requests accommodated
• Chilled or ambient delivery temperature
• Large donor pool
• Comprehensive donor information provided
• Serology screening prior to dispatch
• Samples fully consented including for genetic analysis and commercial research purposes
• HLA typing available on request
Benefits of the frozen stock PBMC inventory
• PBMCs processed and frozen within 5 hours of collection
• Choice of anticoagulant, volume, age, sex, blood group and HLA type
• Select and reserve the samples that meet your research requirements in real time
• High post-thaw viability and minimal degradation
• Large donor pool
• Comprehensive donor information provided
• Serology screening prior to dispatch
• PBMCs batch-tested negative for bacteria and mycoplasma by PCR
• Samples fully consented including for genetic analysis and commercial research purposes
• Frozen PBMCs delivered in dry ice across the BeNeLux
Research Donors provides researchers access to human whole blood for research purposes.
Benefits of using the fresh human blood service of Research Donors
• Delivery on the next day after collection (in the BeNeLux)
• Human whole blood collected to your exact requirements
• Specific donor/protocol requests accommodated
• Choice of anticoagulants and storage devices
• Chilled or ambient delivery temperature
• Large donor pool
• Comprehensive donor information provided
• Serology screening prior to dispatch
• Samples fully consented including for genetic analysis and commercial research purposes
Benefits of the fresh human plasma service
• Delivery on the next day after blood collection (in the BeNeLux)
• Plasma collected to your exact requirements
• Choice of anticoagulants and storage devices
• Chilled, ambient or frozen delivery temperature
• Large donor pool
• Comprehensive donor information provided
• Serology screening prior to dispatch
• Samples fully consented including for genetic analysis and commercial research purposes
Benefits of the frozen stock human plasma inventory
• Choice of anticoagulant, volume, age, sex, blood group and ethnicity
• Select and reserve the samples that meet your research requirements in real time
• Large donor pool
• Comprehensive donor information provided
• Serology screening prior to dispatch
• Samples fully consented including for genetic analysis and commercial research purposes
• Frozen plasma delivered on dry ice across the BeNeLux
Fresh and frozen human serum of Research Donors, collected in clot-activating silica tubes.
Benefits of the fresh human serum service
• Delivery on the next day after collection
• Specific donor and protocol requests accommodated
• Chilled, ambient or frozen delivery temperature
• Large donor pool
• Comprehensive donor information provided
• Serology screening prior to dispatch
• Samples fully consented including for genetic analysis and commercial research purposes
Benefits of the frozen stock human serum inventory
• Choice of volume, age, sex, blood group and ethnicity
• Select and reserve the samples that meet your research requirements in real time
• Large donor pool
• Comprehensive donor information provided
• Serology screening prior to dispatch
• Samples fully consented including for genetic analysis and commercial research purposes
• Frozen serum delivered on dry ice across the BeNeLux
Research Donors provides fresh, healthy human buffy coats. The buffy coats are prepared according to each researcher's exact requirements, with delivery available on the next day after collection in the BeNeLux, offering access to human buffy coat whenever your research demands.
Benefits of our human blood buffy coat service
• Delivery on the next day after collection (in the BeNeLux)
• Buffy coats collected to your exact research requirements
• Choice of anticoagulant and storage device
• Chilled or ambient delivery temperature
• Large pool of healthy donors
• Comprehensive donor information provided
• Serology screening prior to dispatch
• Samples fully consented including for genetic analysis and commercial research purposes
Fresh human red blood cells (RBC) of Research Donors. The fresh human red blood cells are prepared according to each researchers' exact needs, with a choice of volume, anticoagulant, storage device and shipment temperature.
Benefits of our fresh red blood cell service
• Delivery of fresh RBCs on the day after collection
• Available as leuko-reduced RBCs
• Specific donor requests accommodated
• Choice of anticoagulants and storage devices
• Ambient, chilled or frozen delivery temperature
• Large donor pool
• Comprehensive donor information provided
• Serology screening prior to dispatch
• Samples fully consented including for genetic analysis and commercial research purposes
Blood and Biospecimens for precision medical research by Research Donors Who are Research Donors? Research Donors is an HTA-licensed clinic, based in London, dedicated to the collection and processing of human blood and fresh leukopaks for research purposes. Research Donors is ISO 9001 2015 certified with Research Ethics (REC) approval as a Research Tissue bank, [...]
Zymo Research is a globally established biotechnology company and industry leader in the fields of epigenetics, microbiomics and the emerging Next-Gen Sequencing space. With international facilities and a global distribution network, Zymo Research enables researchers in academia and the biomedical field to make cutting-edge discoveries all over the world. While the company provides some of the most technologically advanced products in the industry, everything is driven by the fundamental belief that "the beauty of science is to make things simple."
"The beauty of science is to make things simple"
Their vision is to have a positive impact on the biomedical field and to contribute to the greater good of humanity and their mission is to provide the most reliable, innovative, and valuable biomedical tools and services to the customers through research and strategic development.
Blood Collection Tube
Evacuated blood tube (16 x 100 mm) filled with 6 ml of DNA/RNA Shield™ for the direct collection of 3 ml whole-blood (human or animal).
Fecal Collection Tube
15 ml container (prefilled with 9 ml DNA/RNA Shield™) for the direct collection of up to 1 gram and/or 1 ml stool. Collection spoon is included in the container screwcap.
Microbe & Tissue Lysis Tubes
2 ml collection tube (prefilled with 1 ml DNA/RNA Shield™) and BashingBeads™ for the collection and homogenization of microbial or tissue samples.
Swab and Collection Tube
5 ml screwcap container (12 x 80 mm) filled with 1 ml DNA/RNA Shield™ and a sterile swab for specimen collection.
The EZ-Load™ technology replaces slow gravity flow columns with rapid binding and
washing using a vacuum or centrifuge. The EZ-Elute™ system makes time-consuming
alcohol precipitation steps obsolete by enabling elution of highly concentrated plasmid
DNA from a spin-column using a microcentrifuge. The EndoZero™ Spin-Column removes endotoxins with a simple 1 minute spin.
Fastest: Simple 20 minute Midi/Maxipreps.
Highest Yield: 6x more plasmid.
Ultra-Pure: EndoZero™, vaccine grade, and transfection ready
Fast & Simple: Only 1.5 hours of hands-on time. No TapeStation® analyses or AMPure® clean-ups.
Accurate: Real-time PCR reduces PCR chimera formation by up to 10 times.
Increased Coverage: Novel primers increase phylogenetic coverage of bacteria and archaea, enabling species-level resolution for human microbiome profiling.
New! To our portfolio, Zymo Research Zymo Research is a globally established biotechnology company and industry leader in the fields of epigenetics, microbiomics and the emerging Next-Gen Sequencing space. With international facilities and a global distribution network, Zymo Research enables researchers in academia and the biomedical field to make cutting-edge discoveries all over the world. [...]
