ASC (apoptosis-associated speck-like protein containing a CARD (caspase recruitment domain)) is a 22 kDa soluble protein, located in the cytosol of HL-60 cells. In apoptotic HL-60 cells, it is able to visualized as a speck, forming an insoluble aggregate. The C-terminal domain of this protein contains a CARD, suggesting that ASC may have proapoptotic activity in HL-60 cells. Recent data have indicated that ASC plays a role of adaptor protein linking various PAAD (Pyrin, AIM, ASC, and death domain-like) family proteins to pathways involved in NF-?B and procaspase-1 activation.
Specifications
Applications
ICC, IHC, IP, WB
Size
100 ug
Clonality
Monoclonal
Clone
23-4
Host
Mouse
Supplier
MBL International
Shipping & storage
Shipping condition
Blue Ice
Storage temperature
-20°C