Capsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities.{55276,55277,55278,55279} It induces inward currents in HEK293 cells expressing rat transient receptor potential vanilloid 1 (TRPV1; EC50 = 0.64 uM at neutral pH), an effect that can be blocked by the TRPV1 inhibitor A-425619.{55276} Capsaicin (10 and 50 uM) decreases LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production, as well as reduces LPS- and IFN-induced nitric oxide (NO) release in isolated mouse peritoneal macrophages.{55277} Capsaicin induces substance P release in rat spinal cord slices with an EC50 value of 2.3 uM.{55278} It reduces acetylcholine- or phenylquinone-induced writhing (ED50s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED50 = >20 mg/kg, s.c.).{55279} Formulations containing capsaicin have been used in the treatment of nerve pain associated with shingles.
500 mg
CAS number
Cayman Chemical
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