Satratoxin G is a macrocyclic trichothecene mycotoxin that has been found in S. chartarum.{53279,53280} It induces cleavage of caspase-3 and poly(ADP-ribose) polymerase (PARP) in HL-60 cells when used at a concentration of 40 nM and is cytotoxic to HepG2, Hep-2, Caco-2, A204, U937, and Jurkat cells (IC50s = 2.2-9.7 ng/ml).{53281,53282} Intranasal administration of satratoxin G (500 ?g/kg) induces apoptosis of olfactory sensory neurons in olfactory epithelium and ethmoid turbinate expression of the genes encoding IL-1a, IL-1B, IL-6, TNF-a, and MIP-2 in mice.{53280} Satratoxin G induces lethality in 4 week-old male mice (LD50 = 1.23 mg/kg, i.p.).{53279}
Specifications
Size
500 ug
CAS number
53126-63-9
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C