Cholestanol is a cholesterol metabolite formed by oxidation and an intermediate in the biosynthesis of chenodeoxycholic acid (Item No. 10011286).{47049} Cholestanol (10 ug/ml) induces apoptosis in cornea and lens epithelial cells and increases the activity of IL-1B converting enzyme (ICE) and CPP32 proteases.{47050} Dietary administration of 1% cholestanol to mice increases serum and liver cholestanol levels and leads to corneal opacities and gallstones and in rats it leads to cholestanol deposition in the cerebellum.{47051} Cholestanol levels are increased in plasma of patients with cerebrotendinous xanthomatosis (CTX), a disease characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.{47052}
25 g
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Cayman Chemical
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