Thromboxane B2-d9

Thromboxane B2-d9 (TXB2-d9) is intended for use as an internal standard for the quantification of TXB2 (Item No. 19030) by GC- or LC-MS. TXB2 is a non-enzymatically derived, stable, inactive metabolite of TXA2, which is highly unstable.{488,868,53874} Serum levels of TXB2 positively correlate with platelet COX-1 activation.{53875,53876} Urinary levels of TXB2 reflect intrarenal TXA2 synthesis, while its metabolites, 11-dehydro TXB2 (Item No. 19500) and 2,3-dinor TXB2 (Item No. 19510), reflect systemic TXA2 secretion.{6304,717,868}