(S)-(+)-Linoleyl-2'-Hydroxy-1'-Propylamide

N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Linoleoyl ethanolamide (LOEA) has potential signaling roles in aging and neurological functioning.{19623,11177} LOEA has a weak affinity for cannabinoid (CB) receptors (Ki = 10, 25 ?M for CB1, CB2, respectively) and inhibits voltage-gated K+ channels.{7422,13859} LOEA also inhibits fatty acid amide hydrolase (FAAH; Ki = 9 ?M) and is hydrolyzed by FAAH.{7251,3922} (S)-(+)-Linoleyl-2'-hydroxy-1'-propylamide is a homolog of LOEA, characterized by the addition of an (S)-B-methyl group at the terminal ethanolamine carbon. A similar modification of arachidonoyl ethanolamide (Item No. 90050) to produce S-2 methanandamide (Item No. 90076) imparts higher affinity for the CB receptor.{1092} The physiological actions of this compound have not been evaluated.