N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Eicosapentaenoyl ethanolamide (EPEA) has potential signaling roles in aging, cancer, inflammation, and neurological development.{21496,19917,19740,19623} At least some of EPEA’s effects are mediated through cannabinoid (CB) receptors, while some NAEs also act as vanilloid receptor agonists.{21496,19780} S-(+)-Eicosapentaenyl-2’-hydroxy-1’-propylamide is a homolog of EPEA, characterized by the addition of an (S)-B-methyl group at the terminal ethanolamine carbon. A similar modification of arachidonoyl ethanolamide (Item No. 90050) to produce S-2 methanandamide (Item No. 90076) imparts higher affinity for the CB receptor.{1092} The physiological actions of this compound have not been evaluated.