3-Deazaadenosine

S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferases. 3-Deazaadenosine (3-DZA) is an inhibitor of SAH hydrolase (Ki = 3.9 ?M).{19419,19418} It has anti-inflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-kB signaling.{19415,19416} 3-DZA also has antiviral and antibacterial activities.{19419,19414,19417}