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Dronedarone (hydrochloride)
9000543-100
100 mg
€368
Product description
Dronedarone is an antiarrhythmic agent and a derivative of amiodarone (Item No. 15213).{41032,41033} It inhibits muscarinic acetylcholine receptor-dependent potassium currents induced by carbachol (carbamoylcholine; Item No. 14486) or intracellular loading of GTPyS in single cells isolated from guinea pig atria (IC50s = 0.1 and 1 µM, respectively).{41033} Dronedarone (50 and 100 mg/kg) reduces sinus frequency and prolongs action potential duration (APD) in isolated rabbit ventricular myocardium. It increases atrial APD and the atrial effective refractory period (AERP) in a dog model of atrial fibrillation induced by rapid right atrial pacing.{57286} Formulations containing dronedarone have been used in the treatment of atrial fibrillation.
Specifications
CAS number
141625-93-6
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C
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9000543-100
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9000543-100
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