Oleic acid-d17 is intended for use as an internal standard for the quantification of oleic acid (Item No. 90260) by GC- or LC-MS. Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue.{3964,42296} It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.{3964} Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 ug/ml. It also inhibits fMLF-induced neutrophil aggregation and degranulation by 55 and 68%, respectively, when used at a concentration of 5 uM, similar to arachidonic acid (Item No. 90010 | 90010.1 | 10006607).{2095} Oleic acid (60 uM) induces release of intracellular calcium in human platelets.{4198} In vivo, oleic acid increases TNF-a, IL-8, IL-6, and IL-1B production, neutrophil accumulation, and apoptotic and necrotic cell death in mouse lung and has been used to induce lung injury in a mouse model of acute respiratory distress syndrome (ARDS).{42296}
500 ug
CAS number
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature