Product description
Prostaglandin E1 (PGE1) is produced by the metabolism of dihomo-y-linolenic acid (DGLA) by the cyclooxygenase pathway. PGE1 inhibits platelet aggregation (IC50 = 40 nM){960,4165} and increases vasodilation. 13,14-dihydro-16,16-difluoro PGE1 is an analog of PGE1. 13,14-dihydro PGE1 is a biologically active metabolite of PGE1, inhibiting platelet aggregation with comparable potency to the parent compound.{2126,4165} The addition of two electron-withdrawing fluorine atoms, which should stabilize the molecule against hydrolytic cleavage, may be expected to delay degradation in vivo.{17623}
Specifications
CAS number
475992-30-4
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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13,14-dihydro-16,16-difluoro Prostaglandin E1

9000405-5

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13,14-dihydro-16,16-difluoro Prostaglandin E1

9000405-5

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