Mouse Anti-Chicken CD8a-UNLB

In the chicken, the CD8 molecule is present in two forms - (i) a homodimer of two ? chains and (ii) a heterodimer of an ? chain and a ? chain. While the vast majority of CD8+ cells in the thymus, spleen, and blood of adult chickens express both CD8?- and CD8?-chains, a relatively large proportion of the CD8+ TCR?? cells in the spleens of embryos and young chicks express only the ?-chain of CD8. Among intestinal epithelial lymphocytes, the major CD8+ T cell populations present in mice are conserved but there is a population of TCR?? CD8?? cells in the chicken that is not found in rodents. Chicken CD8 is expressed on approximately 80% of thymocytes, 15% of blood mononuclear cells, and 50% of spleen cells but less than 1% of cells in the bursa and bone marrow. The monoclonal antibody CT-8 recognizes the CD8? chain and has been shown to react to a polymorphic determinant in turkey.