Product description
Troglitazone is a selective agonist of peroxisome proliferator-activated receptor y (PPARy; EC50s = 0.78 and 0.55 ?M for the mouse and human receptors, respectively, in a transactivation assay).{10670} It is selective for PPARy over PPARa and PPARd, at which it is inactive at concentrations up to 10 ?M. Troglitazone (500 mg/kg twice per day) exhibits antihyperglycemic and antihyperlipidemic properties in Zucker diabetic fatty rats, reducing plasma glucose and triglyceride levels by 61 and 87% respectively.{25251} It also induces cell cycle arrest at the G1 phase in SK-HEP-1 and Hep3B hepatocellular carcinoma cells when used at a concentration of 10 ?M and increases apoptosis in these cells at concentrations of 30 ?M and higher.{10669}
Specifications
CAS number
97322-87-7
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

Order your product by email

Productname

Troglitazone

71750-5

By filling out this form, you are placing an order by e-mail. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.


Request a sample

Productname

Troglitazone

71750-5

By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.


Organization information

*Required fields


Are you looking for specific products, alternatives or documentation?