Product description
The pro-angiogenic factor HIF-1a is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-a prolyl hydroxylase (HIF-PH).{8840} 2,4-DPD is a cell permeable, competitive inhibitor of HIF-PH. 2,4-DPD inhibits the hydroxylation of P564 by acting as a competitive inhibitor of the HIF-PH cofactor a-keto glutarate, with effective concentrations in the low µM range.{9005} 2,4-DPD is therefore expected to act as a pro-angiogenic compound, via the HIF-1a system.{9790,8799}
Specifications
CAS number
41438-38-4
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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