Product description
(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen (Item No. 70250) that has diverse biological activities.{16203,16204,16205,39781} It inhibits y-secretase activity in vitro and, in vivo, it reduces formation of amyloid-B peptide 1-42 (AB42) and improves axonal transport in young AB-plaque free mice but not old mice with existing AB plaques in the Tg2576 transgenic model of Alzheimer's disease.{16203,39781} (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-kB and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg.{16204} It also suppresses prostate tumor cell growth in vitro by inducing p75NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.{16205,16204}
Specifications
CAS number
51543-40-9
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Room Temperature
Storage temperature
20-25°C

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