(+-)-Flurbiprofen

(+-)-Flurbiprofen is a non-selective COX inhibitor (IC50s = 0.04 and 0.51 ?M for COX-1 and COX-2, respectively).{1286} In vivo, (+-)-flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats.{39761} (+-)-Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg.{39762} Formulations containing (+-)-flurbiprofen have been used to manage pain and inflammation associated with arthritis.