The monoclonal antibody decorates the lamina, i.e. the nucleoplasmic layer coating the nuclear envelope. Mutations in lamin A have been shown to cause Hutchinson-Gilford progeria syndrome in human and mouse and other laminopathies (for review see Burke & Stewart, 2002).
Polypeptides reacting: Lamin isotypes A and C (Mr 60 - 75 kD); meiotic lamin C2
Reactivity in cultured cell lines: RV-SMC (rat vascular smooth muscle cells)
Antigen recognized in species: