2-Aminoethyl diphenylborinate

2-Aminoethyl diphenylborinate (2-APB) is a modulator of intracellular calcium levels and transient receptor potential (TRP) channels.{60978,60979} It inhibits calcium release induced by inositol-1,4,5-triphosphate (IP3) in rat cerebellar microsomes (IC50 = 42 µM) without affecting IP3 binding to its receptor.{60978} 2-APB inhibits store-operated calcium entry (SOCE) in DT40 cells (IC50 = 4.8 µM), as well as inhibits TRP canonical 6 (TRPC6) and TRP melastatin 8 (TRPM8) and activates TRP vanilloid 1 (TRPV1), TRPV2, and TRPV3 in vitro.{60979,60980} It also inhibits calcium transients induced by the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor thapsigargin (Item No. 10522) in DDT1 MF-2 cells when used at a concentration of 75 µM.{60978} 2-APB inhibits differentiation of primary mouse brown adipocytes when used at concentrations ranging from 30 to 300 µM and reduces adipocyte triglyceride levels at 100 µM.{60981} It also increases the expression of Ucp1 and Pparg in primary mouse brown adipocytes. 2-APB (10 mg/kg) reduces protein levels of TRP melastatin 2 (TRPM2) in the rat hippocampus and improves learning and memory deficits induced by amyloid-B (25-35) in rats.{60982}