anti-Cytokeratin Type II, AE3, purifiedIgG1

AE 3 represents an excellent marker for distinguishing carcinoma from non-epithelial tumors. Tumors specifically detected: All epithelia and their neoplasms.Polypeptide reacting: Mr 53 000 to Mr 67 000 basic type II keratin polypeptides of human epithelial proteins (keratins – formerly also designated cytokeratins - nos. K1 – K8). Epitope has been mapped to aa 266-299 on alpha-helical rod domain (see Waseem et al., 2004).Reactivity on cultured cell lines: MCF-7, A-431, RT 112 Waseem A, Karsten U, Leigh IM, Purkis P, Waseem NH, Lane BE: Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability. Biochemistry 43, 1283-1295 (2004)