anti-Keratin pan, mouse monoclonal, clone lu-5

Lu-5 represents an excellent marker for all types of epithelia. Ideal marker for immunolocalization studies on frozen and paraffin embedded tissue. Useful for distinguishing carcinomas from non-epithelial tumors. Tumors specifically detected: all epithelium-derived neoplasms. Polypeptide reacting: Most keratins present in human epithelia (including keratins – formerly also designated cytokeratins -K1, K5, K6, K14, K18, K19) and most acidic (K31 – KK38) and basic (K81 – K86) hair keratins from human hair follicle. The antibody specifically detects a conformational epitope common to most keratins, but not to other intermediate filament polypeptides. Reactivity on cultured cell lines: MCF-7, PLC, A-431, HeLa; PtK2, A6 (XLKE).