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1A4/ ASM-1 represents an excellent marker for myogenic soft tissue tumors and smooth muscle differentiation. Polypeptide reacting: specific for α-smooth-muscle isoform of actin (Mr 43,000). Tumors specificallly detected: leiomyosarcoma, leiomyoma, certain stromal cells surrounding infiltrating ductal carcinoma of breast. Tested cultured cell lines: Stress fibers of smooth muscle-derived cells and some smooth muscle subtype fibroblasts
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