Product description
c-Kit, also known as stem cell factor receptor, steel factor receptor or CD117 is classified as a type III receptor tyrosine kinase (RTK) belonging to the platelet-derived growth factor receptor subfamily. Binding of stem cell factor (SCF), known as c-Kit ligand to c-Kit, initiates autophosphorylation of the receptor, subsequently leading to promotes a signal transduction cascade through Ras-Raf-MAP kinase cascade, phosphatidylinositol- 3-kinase, src family kinases, and JAK/STAT pathways. The roles of c-Kit include maturation of hematopoietic and primordial germ cells precursors and melanocytes during embryonic development. In acute myeloid leukemia (AML), c-Kit has been proposed to play a functional role, and becomes target molecule for drug development.
Specifications
Applications
IHC, WB, ICC
Host
Rabbit
Clonality
Polyclonal
Supplier
MBL International
Shipping & storage
Shipping condition
Blue Ice
Storage temperature
-20°C

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Anti-CD117 (c-Kit) (Human) pAb

566

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Anti-CD117 (c-Kit) (Human) pAb

566

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