Product description
(+-)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid (Item No. 90010) by cytochrome P450 enzymes.{463,729,39722} A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET.{39722} 11(12)-EET has been shown, along with 8(9)-EET (Item No. 50351), to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells.{5318} It also inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct when used at a concentration of 100 nM.{39723} 11(12)-EET (50 µg/kg per day) increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 but does not affect choroidal neovascularization size following laser photocoagulation.{39724} It also has anti-inflammatory, angiogenic, and cardioprotective properties.{39725}
Specifications
CAS number
123931-40-8
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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