Testosterone glucuronide is a urinary metabolite of the endogenous steroid hormone testosterone.{35430} It is formed by glucuronide conjugation of testosterone primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B17, which is found in the small intestine, colon, and liver.{35430,35431,35432} Testosterone glucuronide levels are lower in individuals with mutations in the UGT2B17 gene.{35433} Glucuronidation of testosterone is decreased by the NSAIDs diclofenac and ibuprofen in vitro, but not in vivo.{35435,35434}
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