Perfluorodecanoic Acid
Perfluorodecanoic acid is a perfluoroalkyl substance (PFAS).{67174} Chronic administration of perfluorodecanoic acid (25 mg/kg per day) induces weight loss and increases liver weight and lipid content in mice.{64753} Perfluorodecanoic acid (25 mg/kg per day) reduces mRNA expression of the genes encoding IL-1?, IL-18, and cellular inhibitor of apoptosis 2 (cIAP2), as well as caspase-1, -3, and -7 in mouse liver. It has been found in marine life and as a contaminant in surface water.{67174,64754} Formulations containing perfluorodecanoic acid have been used commercially as wetting agents and flame retardants.
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