3,5-Diiodo-L-thyronine

3,5-Diiodo-L-thyronine (3,5-T2) is a thyroid hormone metabolite.{64130} It binds to thyroid hormone receptor a1 (TRa1), TRB1, and TRB2 (EC50s = 0.8, 0.79, and 0.1 µM, respectively, in cell-free assays).{64131} 3,5-T2 (1 pM) stimulates oxygen consumption in perfused livers isolated from rats with hypothyroidism induced by sodium iodide.{64132} It reduces subcutaneous and epididymal fat mass, as well as decreases serum leptin and cholesterol levels, without affecting body weight in high-fat diet-induced obese mice when administered at a dose of 2.5 µg/g per day.{64130}