(E/Z)-Ajoene

(E/Z)-Ajoene is a disulfide that has been found in A. sativum and has antitumor and antiplatelet activities.{46867,46870} It is cytotoxic to a variety of cancer cells, including B16-BL6 murine melanoma, and human HT-29 colon adenocarcinoma, MDA-MB-231 mammary, and PANC-1 pancreatic adenocarcinoma cells (IC50s = 18, 19, 7, and 38 µM, respectively).{46867} (E/Z)-Ajoene (25 mg/kg) reduces tumor growth and decreases the number of lung metastases in B16-BL6 murine models of melanoma. It also prevents thrombus formation in heparinized animals in a porcine model of severe vascular damage induced by intimal stripping and tunica media exposure when administered at a dose of 25 mg/kg.{46870}