Product description
680C91 is an inhibitor of tryptophan 2,3-dioxygenase (TDO; IC50s = 1.46 and 0.28 µM for the mouse and human enzymes, respectively).{61677} It is selective for TDO over indoleamine 2,3-dioxygenase (IDO; IC50 = >80 µM for the mouse enzyme). 680C91 (40 µM) inhibits the migration of SK-MEL-28 melanoma cells induced by dexamethasone (Item No. 11015).{61678} It increases brain levels of tryptophan, serotonin (5-HT), and 5-hydroxy indole-3-acetic acid (5-HIAA) in rats in a dose-dependent manner.{61679}
Specifications
CAS number
163239-22-3
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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