Product description
8-Azaadenosine is a purine nucleoside analog and an inhibitor of adenosine deaminase acting on RNA 1 (ADAR1), an enzyme that converts adenosine to inosine in dsRNA, a post-transcriptional modification known as A-to-I editing.{62405} It inhibits RNA A-to-I editing in, as well as the invasion and migration of, TPC-1 and Cal-62 thyroid cancer cells when used at concentrations of 1 and 2 µM. 8-Azaadenosine (2 mg/kg) increases the ex vivo secretion of IFN-y and TNF-a from CD8+ T cells isolated from mouse spleen in a model of hepatitis B virus (HBV) infection.{62406} It decreases serum levels of HBV surface antigen (HBsAg) in the same model.
Specifications
CAS number
10299-44-2
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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8-Azaadenosine

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