7-ethyl Camptothecin

7-ethyl Camptothecin is a derivative of camptothecin (Item No. 11694) and an anticancer agent.{63212,63213} It inhibits wild-type but not Gly533 mutant topoisomerase I in RPMI-8402 and CPT-K5 cells, respectively (IC50s = 5.48 and >2,500 nM, respectively).{63212} 7-ethyl Camptothecin is cytotoxic to ADJ/PC6 SN-38-sensitive and PC6/SN2-5H2 SN-38-resistant cells (IC50s = 0.85 and 2.98 nM, respectively). In vivo, 7-ethyl camptothecin (0.25-3 mg/kg per day) increases survival in Ehrlich, MM46, Meth A, L1210, P388, and B16/F10 mouse ascites tumor models.{63213}