Product description
(+-)12-HETE is a racemic mixture of the arachidonic acid metabolites 12(R)-HETE (Item No. 34560) and 12(S)-HETE (Item No. 34570). It is formed via non-enzymatic oxidation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607).{54364,54411} 12(S)- and 12(R)-HETE are formed by 12S- and 12R-lipoxygenase-mediated oxidation of arachidonic acid, respectively.{59716,54718,584} 12(R)-HETE can also be formed by oxidation of arachidonic acid mediated by cytochrome P450 (CYP450) enzymes.{54364} (+-)12-HETE (1 µM) induces aggregation of isolated human neutrophils.{2091} Production of (+-)12-HETE by platelets isolated from spontaneously hypertensive rats is increased compared with platelets isolated from normotensive rats.{3138}
Specifications
CAS number
71030-37-0
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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