4-oxo Isotretinoin

4-oxo Isotretinoin is an active metabolite of the retinoid isotretinoin (Item No. 21648).{62247} It is formed from isotretinoin by several cytochrome P450 (CYP450) isoforms, including CYP3A, CYP2B6, and CYP2C19.{62248} 4-oxo Isotretinoin (10 µM) increases protein expression of cytokeratin 7 (CK7) and CK19 in normal human epidermal keratinocytes.{62249} It inhibits proliferation of retinoid-sensitive UM-SCC-22A and UM-SCC-35 head and neck squamous cell carcinoma (HNSCC) cells in a concentration-dependent manner.{62250} 4-oxo Isotretinoin has been found in influent and effluent wastewater.{62251} It is teratogenic to mouse embryos when administered to pregnant dams at a dose of 100 mg/kg on day 11 of gestation.{62252}