5,7-Dihydroxy-4-methylcoumarin

5,7-Dihydroxy-4-methylcoumarin is a synthetic coumarin with diverse biological activities.{62116,62117,62118,62119,62120,62121,62122} It scavenges alkylperoxy radicals and hypochlorous acid (HOCl; IC50 = 2.85 µM) in cell-free assays, as well as inhibits lipid peroxidation in rat liver microsomes, A23187-induced thromboxane B2 (TXB2; Item No. 19030) generation in isolated rat peritoneal leukocytes, and myeloperoxidase (MPO) activity in a cell-free assay (IC50s = 12, 1, and 1.06 µM, respectively).{62116,62117} 5,7-Dihydroxy-4-methylcoumarin also inhibits rat lens aldose reductase (IC50 = 17 µM) and human carbonic anhydrase I (CAI), CAIX, and CAXII with Ki values of 8.4, 0.19, and 6.4 µM, respectively.{62118,62119} It inhibits platelet aggregation induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) with an IC50 value of 45 µM.{62121} 5,7-Dihydroxy-4-methylcoumarin inhibits hepatitis C virus (HCV) non-structural protein 5B (NS5B) polymerase (IC50 = 47.2 µM).{62120} It is active against H. pylori with an MIC value of 10 µg/ml.{62122}