Product description
4-hydroxy Estrone is a metabolite of the endogenous estrogen estrone (Item No. 10006485).{57564} It is formed from estrone primarily by the cytochrome P450 (CYP) isoforms CYP1B1, CYP1A2, and CYP1A1. 4-hydroxy Estrone (5 µM) induces nuclear translocation of phosphorylated p53 and is protective against glutamate-induced oxidative death in HT22 hippocampal neuronal cells.{57565} It reduces neurodegeneration induced by kainic acid in the rat hippocampus and improves working memory in the Y-maze in rats when administered at a dose of 10 µg/animal. 4-hydroxy Estrone also inhibits proliferation of MCF-7 and MDA-MB-231 breast cancer cells with IC50 values of 30 and 38 µM, respectively.{28444}
Specifications
CAS number
3131-23-5
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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