1-Palmitoyl-d9 Lysophosphatidic Acid

1-Palmitoyl-d9 lysophosphatidic acid (1-palmitoyl-d9 LPA) is intended for use as an internal standard for the quantification of 1-palmitoyl LPA (Item Nos. 10010094 | 10010290) by GC- or LC-MS. 1-Palmitoyl LPA is an analog of LPA that contains palmitic acid (Item No. 10006627) at the sn-1 position. It induces reporter gene expression in PC12 cells expressing human lysophosphatidic acid receptor 4 (LPA4) when used at concentrations ranging from 0.01 to 10 µM.{13001} 1-Palmitoyl LPA (12-300 µM) induces aggregation of isolated human platelets, an effect that can be reversed by prostaglandin E1 (PGE1; Item No. 13010), theophylline (Item No. 23760), or EDTA.{60572} It also binds to calcium and magnesium and enhances the activity of ampicillin (Item No. 14417), piperacillin (Item No. 20766), and ceftazidime (Item No. 14828) against P. aeruginosa isolates from patients with cystic fibrosis.{15000}