Product description
5a-Androst-16-en-3a-ol is a steroid pheromone that has been found in boar testes and human male axillary sweat and has diverse biological activities.{57543,57544} It enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50 = 0.4 µM).{57544} 5a-Androst-16-en-3a-ol (0.1-1 µM) increases the amplitude of GABA-activated currents in HEK293 cells expressing human a1B2y2 and a2B2y2 subunit-containing GABAA receptors. In vivo, 5a-androst-16-en-3a-ol (5-10 mg/kg) decreases immobility time in the forced swim test in mice. It increases time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity, when administered at doses ranging from 30 to 50 mg/kg. 5a-Androst-16-en-3a-ol protects against seizures induced by pentylenetetrazole (PTZ; Item No. 18682) or electroshock in mice (ED50s = 48.9 and 21.9 mg/kg, respectively).
Specifications
CAS number
1153-51-1
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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33457-50

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