(-)-Sweroside

(-)-Sweroside is an iridoid glycoside that has been found in L. japonica and has diverse biological activities, including anti-inflammatory, antiproliferative, and anti-obesity properties.{60316,60317,60318} It inhibits LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010) and reactive oxygen species (ROS) in mouse RAW 264.7 macrophages when used at a concentration of 40 µM.{60316} (-)-Sweroside inhibits the growth of U937 lymphoma and HL-60 leukemia cells (IC50s = 67.92 and 62.58 µM, respectively) but not non-cancerous human peripheral blood mononuclear cells (PBMCs) or mouse bone marrow cells (BMCs).{60317} It reduces tumor growth in an HL-60 mouse xenograft model when administered at a dose of 50 mg/kg. (-)-Sweroside (120 mg/kg) reduces weight gain and serum total cholesterol, triglyceride, LDL cholesterol (LDL-C), and free fatty acid (FFA) levels in a mouse model of obesity induced by a high-fat diet (HFD).{60318}