1-BCP

1-BCP is a positive allosteric modulator of AMPA receptors.{61290,61291,61292} 1-BCP (1 mM) selectively increases the release of norepinephrine induced by AMPA, but not NMDA or kainic acid, in rat hippocampal slices.{61290} It increases the amplitude and duration of primed field excitatory postsynaptic potentials (EPSPs) in rat hippocampal slices (EC50s = 480 and 590 µM, respectively).{61291} 1-BCP enhances memory in two-odor discrimination and radial maze tests, as well as in the Morris water maze, in rats when administered at a dose of 120 mg/kg.{61292}