Product description
17a-Hydroxyprogesterone (17-OHP) is a steroid and precursor in the synthesis of adrenal androgens.{54784,54785} It binds to the glucocorticoid receptor in a cell-free assay (IC50 = 82 nM for the human receptor) and induces glucocorticoid receptor transactivation in HEK293 cells (EC50 = 1.2 µM).{54785} 17-OHP (0.005-1 µM) inhibits aldosterone-induced transactivation of the mineralocorticoid receptor in cell-based assays.{54784} Serum levels of 17-OHP are increased in patients with congenital adrenal hyperplasia.{54784,54785}
Specifications
CAS number
68-96-2
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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