28-Acetylbetulin

28-Acetylbetulin is a lupane triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin (Item No. 11041) that has been found in M. chiapensis and has anti-inflammatory and anticancer activities.{62031,62032} It inhibits LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) production by 55.9 and 69.5%, respectively, in RAW 264.7 cells (IC50s = 4.7 and 1.7 µM, respectively).{62031} 28-Acetylbetulin induces cytotoxicity in a variety of cancer cells, including A549, HT-29, and MCF-7 cells (IC50s = 14.37, 10.96, and 11.38 µM, respectively).{62032}