11-Dehydrocorticosterone

11-Dehydrocorticosterone is an endogenous mineralocorticoid.{59726,59727,59728} It increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration-dependent manner.{59726,59727} 11-Dehydrocorticosterone decreases the sodium/creatine ratio and increases the potassium/creatine ratio in rat urine in a dose-dependent manner in a model of 11B-hydroxysteroid dehydrogenase inhibition induced by carbenoxolone (Item No. 18240).{59728} Chronic administration 11-dehydrocorticosterone increases plasma glucocorticoids levels, body weight gain, and adiposity, as well as induces insulin resistance in mice.{59729}