(+-)15-HEPE

(+-)15-HEPE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEPE and 15(S)-HEPE (Item No. 32710). 15(S)-HEPE is formed from EPA via a 15(S)-HpEPE (Item No. 42710) intermediate, which is produced by 15-lipoxygenase (15-LO) and reduced by glutathione peroxidase (GPX).{6407,54203} (+-)15-HEPE is active against P. acnes and S. aureus (MICs = 128 and 512 mg/L, respectively).{64713} It inhibits aggregation of isolated rat neutrophils induced by the formyl peptide receptor agonist fMLP (IC50 = 4.7 µM).{64714} Bronchoalveolar lavage fluid (BALF) levels of (+-)15-HEPE are increased in patients with allergic asthma or COVID-19.{49189,57657}