5,6-Dihydrouridine

5,6-Dihydrouridine is a pyrimidine nucleoside and derivative of uridine (Item No. 20300). It is present in, and provides conformational flexibility to, tRNA from bacteria, eukaryotes, and some archaea.{58248,58249} 5,6-Dihydrouridine inhibits E. coli cytidine deaminase in a cell-free assay (Ki = 3.4 µM).{31865} Serum levels of 5,6-dihydrouridine are increased in patients with prostate cancer and positively correlated with lethality.{58250}