Product description
4-1BB, also known as CD137, is a type I transmembrane glycoprotein and member of the TNF receptor superfamily with roles in T cell-mediated immunity.{54192} It is composed of an N-terminal extracellular domain comprised of a signaling sequence and four cysteine-rich pseudo repeats (CRDs), a helical transmembrane domain, and a cytoplasmic signaling domain.{52821} 4-1BB is transiently expressed on antigen-primed activated T cells, activated natural killer (NK) cells, and mature dendritic cells. Binding of homotrimeric 4-1BB ligand on antigen-primed T cells induces NF-kB and MAPK signaling through TNF receptor-associated factors (TRAFs) and, when the T cell is co-stimulated by other factors, induces PI3K signaling.{54191,54192} This bidirectional signaling event promotes clonal expansion, differentiation, and survival of T cells, as well as polarizes T helper cells.{52822} Knockout of Tnfrsf9, the gene encoding 4-1BB, reduces pancreatic islet accumulation of B-cell-autoreactive CD8+ T cells in a mouse model of type 1 diabetes mellitus. Administration of an anti-4-1BB antibody prolongs survival and reverses renal damage, production of autoantibodies, and immune complex deposition in lupus-prone NZB X NZW F1 mice. Cayman’s 4-1BB/CD137 Extracellular Domain (human, recombinant) protein can be used for ELISA. This protein is a disulfide-linked homodimer. The reduced monomer, comprised of 4-1BB (amino acids 25-186) fused to His-tagged human IgG1 Fc at its C-terminus, consists of 409 amino acids, has a calculated molecular weight of 45.2 kDa, and a predicted N-terminus of Gln25 after signal peptide cleavage. As a result of glycosylation, the monomer migrates at approximately 60 to 65 kDa by SDS-PAGE under reducing conditions.
Specifications
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-80°C

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4-1BB/CD137 Extracellular Domain (human, recombinant)

31825-100

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4-1BB/CD137 Extracellular Domain (human, recombinant)

31825-100

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